| month | day | visitor | score | home | score |
|---|
| November | 3, 2020 | Bobcats | 83 | Spurs | 80 |
| November | 4, 2020 | Blazers | 81 | Spurs | 84 |
| November | 5, 2020 | Spurs | 74 | Magic | 76 |
| November | 8, 2020 | Nets | 97 | Spurs | 71 |
| November | 9, 2020 | Wizards | 85 | Spurs | 82 |
| November | 10, 2020 | Spurs | 83 | Rockets | 76 |
| November | 12, 2020 | Spurs | 68 | Warriors | 87 |
| November | 15, 2020 | Pelicans | 115 | Spurs | 80 |
| November | 17, 2020 | Rockets | 77 | Spurs | 78 |
| November | 18, 2020 | Spurs | 92 | Pelicans | 128 |
| November | 19, 2020 | Grizzlies | 70 | Spurs | 88 |
| November | 20, 2020 | Spurs | 69 | Wizards | 81 |
| November | 24, 2020 | Spurs | 77 | Wolves | 103 |
| November | 25, 2020 | Wolves | 98 | Spurs | 55 |
| November | 28, 2020 | Heat | 93 | Spurs | 63 |
| November | 29, 2020 | Spurs | 78 | Jazz | 105 |
| December | 1, 2020 | Suns | 95 | Spurs | 89 |
| December | 5, 2020 | Spurs | 73 | Clippers | 77 |
| December | 6, 2020 | Spurs | 71 | Nets | 91 |
| December | 8, 2020 | Mavericks | 64 | Spurs | 66 |
| December | 9, 2020 | Spurs | 83 | Blazers | 75 |
| December | 14, 2020 | Spurs | 72 | Hawks | 76 |
| December | 16, 2020 | Spurs | 81 | Heat | 83 |
| December | 19, 2020 | Spurs | 80 | Pacers | 86 |
| December | 22, 2020 | Spurs | 80 | Bulls | 88 |
| December | 23, 2020 | Warriors | 74 | Spurs | 83 |
| December | 28, 2020 | Spurs | 95 | Suns | 108 |
| December | 29, 2020 | Magic | 88 | Spurs | 78 |
| January | 1, 2021 | Spurs | 100 | Sonics | 107 |
| January | 2, 2021 | Hawks | 77 | Spurs | 96 |
| January | 5, 2021 | Spurs | 72 | Bucks | 98 |
| January | 11, 2021 | Spurs | 73 | Clippers | 118 |
| January | 15, 2021 | Spurs | 96 | Kings | 109 |
| January | 19, 2021 | Sonics | 92 | Spurs | 89 |
| January | 20, 2021 | Clippers | 111 | Spurs | 84 |
| January | 24, 2021 | Spurs | 63 | Blazers | 75 |
| January | 25, 2021 | Sonics | 114 | Spurs | 87 |
| January | 27, 2021 | Spurs | 90 | Suns | 116 |
| January | 29, 2021 | Celtics | 83 | Spurs | 64 |
| January | 31, 2021 | Spurs | 83 | Knicks | 103 |
| February | 2, 2021 | Clippers | 123 | Spurs | 68 |
| February | 4, 2021 | Nuggets | 84 | Spurs | 92 |
| February | 5, 2021 | Kings | 109 | Spurs | 95 |
| February | 6, 2021 | Lakers | 102 | Spurs | 86 |
| February | 7, 2021 | Spurs | 73 | Celtics | 84 |
| February | 11, 2021 | Warriors | 96 | Spurs | 98 |
| February | 12, 2021 | Spurs | 68 | Nuggets | 91 |
| February | 13, 2021 | Spurs | 77 | Pistons | 85 |
| February | 14, 2021 | Spurs | 91 | Bobcats | 96 |
| February | 15, 2021 | Raptors | 79 | Spurs | 74 |
| February | 16, 2021 | Spurs | 96 | Lakers | 103 |
| February | 17, 2021 | Jazz | 82 | Spurs | 79 |
| February | 22, 2021 | Spurs | 86 | Pelicans | 108 |
| February | 23, 2021 | Spurs | 88 | Kings | 118 |
| February | 25, 2021 | Spurs | 85 | Mavericks | 83 |
| February | 26, 2021 | Spurs | 75 | Sonics | 92 |
| February | 27, 2021 | Knicks | 88 | Spurs | 95 |
| February | 28, 2021 | Pacers | 92 | Spurs | 77 |
| March | 3, 2021 | Bucks | 88 | Spurs | 78 |
| March | 5, 2021 | Bulls | 94 | Spurs | 53 |
| March | 6, 2021 | Spurs | 75 | 76ers | 67 |
| March | 7, 2021 | Spurs | 74 | Grizzlies | 84 |
| March | 8, 2021 | Kings | 88 | Spurs | 81 |
| March | 9, 2021 | Spurs | 61 | Jazz | 89 |
| March | 10, 2021 | Rockets | 87 | Spurs | 74 |
| March | 11, 2021 | Spurs | 76 | Wolves | 113 |
| March | 12, 2021 | Jazz | 63 | Spurs | 79 |
| March | 14, 2021 | Spurs | 84 | Grizzlies | 73 |
| March | 19, 2021 | Mavericks | 71 | Spurs | 82 |
| March | 26, 2021 | Spurs | 103 | Raptors | 98 |
| March | 30, 2021 | Suns | 87 | Spurs | 83 |
| April | 4, 2021 | Spurs | 94 | Lakers | 96 |
| April | 10, 2021 | Spurs | 54 | Warriors | 85 |
| April | 12, 2021 | Spurs | 90 | Cavaliers | 84 |
| April | 16, 2021 | Lakers | 105 | Spurs | 85 |
| April | 20, 2021 | Spurs | 68 | Mavericks | 75 |
| April | 21, 2021 | Grizzlies | 69 | Spurs | 84 |
| April | 23, 2021 | 76ers | 70 | Spurs | 82 |
| April | 24, 2021 | Pelicans | 120 | Spurs | 75 |
| April | 25, 2021 | Nuggets | 111 | Spurs | 97 |
| April | 27, 2021 | Pistons | 60 | Spurs | 83 |
| April | 29, 2021 | Cavaliers | 85 | Spurs | 82 |