| month | day | visitor | score | home | score |
|---|
| November | 2, 2021 | Spurs | 90 | Celtics | 123 |
| November | 3, 2021 | Spurs | 81 | Jazz | 90 |
| November | 7, 2021 | Spurs | 83 | Rockets | 87 |
| November | 8, 2021 | Nuggets | 79 | Spurs | 93 |
| November | 10, 2021 | Spurs | 90 | Suns | 91 |
| November | 12, 2021 | Spurs | 90 | Rockets | 95 |
| November | 13, 2021 | Spurs | 69 | Jazz | 78 |
| November | 14, 2021 | Rockets | 88 | Spurs | 81 |
| November | 18, 2021 | Spurs | | Nuggets | |
| November | 21, 2021 | Spurs | | Grizzlies | |
| November | 27, 2021 | Spurs | | Jazz | |
| November | 29, 2021 | Spurs | | Suns | |
| November | 30, 2021 | Spurs | | Pistons | |
| December | 2, 2021 | Spurs | | Nuggets | |
| December | 5, 2021 | Timberwolves | | Spurs | |
| December | 6, 2021 | Spurs | | Lakers | |
| December | 7, 2021 | Rockets | | Spurs | |
| December | 9, 2021 | Sonics | | Spurs | |
| December | 10, 2021 | Jazz | | Spurs | |
| December | 11, 2021 | Rockets | | Spurs | |
| December | 12, 2021 | Suns | | Spurs | |
| December | 14, 2021 | Timberwolves | | Spurs | |
| December | 15, 2021 | Rockets | | Spurs | |
| December | 16, 2021 | Knicks | | Spurs | |
| December | 17, 2021 | Lakers | | Spurs | |
| December | 18, 2021 | 76ers | | Spurs | |
| December | 19, 2021 | Spurs | | Sonics | |
| December | 20, 2021 | Spurs | | Timberwolves | |
| December | 25, 2021 | Spurs | | Clippers | |
| December | 26, 2021 | Spurs | | Jazz | |
| December | 29, 2021 | Spurs | | Nuggets | |
| December | 30, 2021 | Clippers | | Spurs | |
| December | 31, 2021 | Lakers | | Spurs | |
| January | 3, 2022 | Timberwolves | | Spurs | |
| January | 7, 2022 | Spurs | | Nuggets | |
| January | 8, 2022 | Spurs | | Clippers | |
| January | 9, 2022 | Lakers | | Spurs | |
| January | 11, 2022 | Heat | | Spurs | |
| January | 12, 2022 | Spurs | | Sonics | |
| January | 19, 2022 | Raptors | | Spurs | |
| January | 23, 2022 | Warriors | | Spurs | |
| January | 24, 2022 | Spurs | | 76ers | |
| January | 25, 2022 | Cavaliers | | Spurs | |
| January | 26, 2022 | Timberwolves | | Spurs | |
| February | 5, 2022 | Spurs | | Timberwolves | |
| February | 6, 2022 | Spurs | | Knicks | |
| February | 9, 2022 | Jazz | | Spurs | |
| February | 12, 2022 | Grizzlies | | Spurs | |
| February | 15, 2022 | Sonics | | Spurs | |
| February | 16, 2022 | Spurs | | Lakers | |
| February | 18, 2022 | Bulls | | Spurs | |
| February | 20, 2022 | Warriors | | Spurs | |
| February | 21, 2022 | Rockets | | Spurs | |
| February | 22, 2022 | Spurs | | Hornets | |
| February | 24, 2022 | Pistons | | Spurs | |
| February | 26, 2022 | Hornets | | Spurs | |
| February | 28, 2022 | Nuggets | | Spurs | |
| March | 1, 2022 | Spurs | | Warriors | |
| March | 3, 2022 | Jazz | | Spurs | |
| March | 4, 2022 | Spurs | | Heat | |
| March | 5, 2022 | Clippers | | Spurs | |
| March | 7, 2022 | Suns | | Spurs | |
| March | 8, 2022 | Lakers | | Spurs | |
| March | 10, 2022 | Spurs | | Nuggets | |
| March | 11, 2022 | Sonics | | Spurs | |
| March | 15, 2022 | Sonics | | Spurs | |
| March | 18, 2022 | Suns | | Spurs | |
| March | 19, 2022 | Warriors | | Spurs | |
| March | 20, 2022 | Spurs | | Raptors | |
| March | 22, 2022 | Spurs | | Warriors | |
| March | 24, 2022 | Spurs | | Bulls | |
| March | 29, 2022 | Spurs | | Jazz | |
| March | 31, 2022 | Spurs | | Warriors | |
| April | 1, 2022 | Celtics | | Spurs | |
| April | 2, 2022 | Spurs | | Sonics | |
| April | 6, 2022 | Suns | | Spurs | |
| April | 8, 2022 | Spurs | | Clippers | |
| April | 9, 2022 | Spurs | | Suns | |
| April | 11, 2022 | Spurs | | Clippers | |
| April | 16, 2022 | Spurs | | Timberwolves | |
| April | 18, 2022 | Spurs | | Cavaliers | |
| April | 20, 2022 | Spurs | | Lakers | |