| month | day | visitor | score | home | score |
|---|
| November | 3, 2021 | Cavaliers | 118 | Celtics | 144 |
| November | 4, 2021 | Bulls | 89 | Cavaliers | 80 |
| November | 5, 2021 | Cavaliers | 111 | Grizzlies | 95 |
| November | 9, 2021 | Hornets | 98 | Cavaliers | 91 |
| November | 13, 2021 | Cavaliers | 101 | Knicks | 119 |
| November | 15, 2021 | Raptors | 112 | Cavaliers | 107 |
| November | 17, 2021 | Raptors | | Cavaliers | |
| November | 22, 2021 | Cavaliers | | Sonics | |
| November | 23, 2021 | Grizzlies | | Cavaliers | |
| November | 25, 2021 | Cavaliers | | 76ers | |
| November | 28, 2021 | Celtics | | Cavaliers | |
| November | 29, 2021 | Cavaliers | | Pistons | |
| November | 30, 2021 | Cavaliers | | Jazz | |
| December | 1, 2021 | Cavaliers | | Heat | |
| December | 2, 2021 | Cavaliers | | Raptors | |
| December | 4, 2021 | Heat | | Cavaliers | |
| December | 6, 2021 | Jazz | | Cavaliers | |
| December | 7, 2021 | Cavaliers | | Raptors | |
| December | 8, 2021 | Bulls | | Cavaliers | |
| December | 9, 2021 | Heat | | Cavaliers | |
| December | 11, 2021 | Cavaliers | | Pistons | |
| December | 12, 2021 | Cavaliers | | Bulls | |
| December | 16, 2021 | Celtics | | Cavaliers | |
| December | 17, 2021 | Cavaliers | | Grizzlies | |
| December | 18, 2021 | Hornets | | Cavaliers | |
| December | 22, 2021 | Cavaliers | | 76ers | |
| December | 23, 2021 | Bulls | | Cavaliers | |
| December | 26, 2021 | Bulls | | Cavaliers | |
| December | 27, 2021 | Cavaliers | | Heat | |
| December | 29, 2021 | Cavaliers | | Grizzlies | |
| December | 31, 2021 | 76ers | | Cavaliers | |
| January | 3, 2022 | Hornets | | Cavaliers | |
| January | 4, 2022 | Pistons | | Cavaliers | |
| January | 5, 2022 | Cavaliers | | Bulls | |
| January | 6, 2022 | Hornets | | Cavaliers | |
| January | 8, 2022 | 76ers | | Cavaliers | |
| January | 9, 2022 | Cavaliers | | Pistons | |
| January | 11, 2022 | Warriors | | Cavaliers | |
| January | 14, 2022 | Cavaliers | | Nuggets | |
| January | 17, 2022 | Clippers | | Cavaliers | |
| January | 18, 2022 | Pistons | | Cavaliers | |
| January | 19, 2022 | Cavaliers | | Celtics | |
| January | 22, 2022 | Cavaliers | | Heat | |
| January | 24, 2022 | Suns | | Cavaliers | |
| January | 25, 2022 | Cavaliers | | Spurs | |
| January | 26, 2022 | Pistons | | Cavaliers | |
| January | 29, 2022 | Cavaliers | | Hornets | |
| February | 7, 2022 | Knicks | | Cavaliers | |
| February | 8, 2022 | Nuggets | | Cavaliers | |
| February | 9, 2022 | Knicks | | Cavaliers | |
| February | 10, 2022 | Cavaliers | | Raptors | |
| February | 20, 2022 | 76ers | | Cavaliers | |
| February | 21, 2022 | Cavaliers | | Pistons | |
| February | 22, 2022 | Cavaliers | | Knicks | |
| February | 23, 2022 | Cavaliers | | Lakers | |
| February | 27, 2022 | Cavaliers | | 76ers | |
| February | 28, 2022 | Cavaliers | | Warriors | |
| March | 1, 2022 | Heat | | Cavaliers | |
| March | 3, 2022 | Timberwolves | | Cavaliers | |
| March | 5, 2022 | Cavaliers | | Grizzlies | |
| March | 7, 2022 | Raptors | | Cavaliers | |
| March | 9, 2022 | Rockets | | Cavaliers | |
| March | 10, 2022 | Cavaliers | | Hornets | |
| March | 11, 2022 | Cavaliers | | Timberwolves | |
| March | 12, 2022 | Knicks | | Cavaliers | |
| March | 14, 2022 | Grizzlies | | Cavaliers | |
| March | 16, 2022 | Sonics | | Cavaliers | |
| March | 17, 2022 | Grizzlies | | Cavaliers | |
| March | 20, 2022 | Cavaliers | | Suns | |
| March | 21, 2022 | Cavaliers | | Heat | |
| March | 25, 2022 | Lakers | | Cavaliers | |
| March | 26, 2022 | Knicks | | Cavaliers | |
| March | 29, 2022 | Cavaliers | | Celtics | |
| March | 30, 2022 | Cavaliers | | Rockets | |
| March | 31, 2022 | Cavaliers | | 76ers | |
| April | 3, 2022 | Cavaliers | | Knicks | |
| April | 6, 2022 | Cavaliers | | Raptors | |
| April | 10, 2022 | Cavaliers | | Celtics | |
| April | 14, 2022 | Cavaliers | | Clippers | |
| April | 17, 2022 | Celtics | | Cavaliers | |
| April | 18, 2022 | Spurs | | Cavaliers | |
| April | 19, 2022 | Bulls | | Cavaliers | |