| month | day | visitor | score | home | score |
|---|
| November | 4, 2021 | Bulls | 89 | Cavaliers | 80 |
| November | 5, 2021 | Bulls | 108 | 76ers | 111 |
| November | 6, 2021 | Bulls | 104 | Sonics | 81 |
| November | 7, 2021 | Heat | 98 | Bulls | 111 |
| November | 8, 2021 | Jazz | 82 | Bulls | 84 |
| November | 10, 2021 | Pistons | 78 | Bulls | 81 |
| November | 11, 2021 | Bulls | 84 | Pistons | 59 |
| November | 14, 2021 | Bulls | 92 | Lakers | 103 |
| November | 16, 2021 | Heat | 107 | Bulls | 103 |
| November | 17, 2021 | 76ers | | Bulls | |
| November | 18, 2021 | Bulls | | Celtics | |
| November | 19, 2021 | Celtics | | Bulls | |
| November | 21, 2021 | Hornets | | Bulls | |
| November | 22, 2021 | Bulls | | Raptors | |
| November | 23, 2021 | Hornets | | Bulls | |
| November | 24, 2021 | Bulls | | Nuggets | |
| November | 25, 2021 | Grizzlies | | Bulls | |
| November | 28, 2021 | Sonics | | Bulls | |
| December | 1, 2021 | Clippers | | Bulls | |
| December | 7, 2021 | Hornets | | Bulls | |
| December | 8, 2021 | Bulls | | Cavaliers | |
| December | 12, 2021 | Cavaliers | | Bulls | |
| December | 13, 2021 | Bulls | | Raptors | |
| December | 15, 2021 | 76ers | | Bulls | |
| December | 16, 2021 | Nuggets | | Bulls | |
| December | 17, 2021 | Timberwolves | | Bulls | |
| December | 18, 2021 | Bulls | | Grizzlies | |
| December | 19, 2021 | Bulls | | Celtics | |
| December | 20, 2021 | Bulls | | Heat | |
| December | 23, 2021 | Bulls | | Cavaliers | |
| December | 24, 2021 | Bulls | | Rockets | |
| December | 25, 2021 | Bulls | | Pistons | |
| December | 26, 2021 | Bulls | | Cavaliers | |
| December | 27, 2021 | Pistons | | Bulls | |
| December | 28, 2021 | Raptors | | Bulls | |
| December | 30, 2021 | Heat | | Bulls | |
| December | 31, 2021 | Bulls | | Grizzlies | |
| January | 2, 2022 | Bulls | | Suns | |
| January | 4, 2022 | Warriors | | Bulls | |
| January | 5, 2022 | Cavaliers | | Bulls | |
| January | 7, 2022 | Bulls | | Hornets | |
| January | 14, 2022 | Bulls | | Clippers | |
| January | 15, 2022 | Bulls | | 76ers | |
| January | 16, 2022 | Knicks | | Bulls | |
| January | 20, 2022 | Bulls | | Warriors | |
| January | 22, 2022 | Grizzlies | | Bulls | |
| January | 26, 2022 | Bulls | | Hornets | |
| February | 9, 2022 | Bulls | | Pistons | |
| February | 10, 2022 | Celtics | | Bulls | |
| February | 13, 2022 | Raptors | | Bulls | |
| February | 14, 2022 | Bulls | | Timberwolves | |
| February | 15, 2022 | Bulls | | 76ers | |
| February | 17, 2022 | Bulls | | Grizzlies | |
| February | 18, 2022 | Bulls | | Spurs | |
| February | 25, 2022 | Bulls | | Celtics | |
| February | 27, 2022 | Bulls | | Pistons | |
| February | 28, 2022 | Bulls | | Grizzlies | |
| March | 2, 2022 | Bulls | | 76ers | |
| March | 3, 2022 | Hornets | | Bulls | |
| March | 12, 2022 | Celtics | | Bulls | |
| March | 13, 2022 | Lakers | | Bulls | |
| March | 15, 2022 | Bulls | | Jazz | |
| March | 16, 2022 | 76ers | | Bulls | |
| March | 18, 2022 | Bulls | | Knicks | |
| March | 19, 2022 | Grizzlies | | Bulls | |
| March | 23, 2022 | Raptors | | Bulls | |
| March | 24, 2022 | Spurs | | Bulls | |
| March | 25, 2022 | Bulls | | Raptors | |
| March | 28, 2022 | Pistons | | Bulls | |
| March | 30, 2022 | Pistons | | Bulls | |
| April | 4, 2022 | Knicks | | Bulls | |
| April | 5, 2022 | Knicks | | Bulls | |
| April | 7, 2022 | Bulls | | Raptors | |
| April | 9, 2022 | Heat | | Bulls | |
| April | 10, 2022 | Bulls | | Knicks | |
| April | 11, 2022 | Bulls | | Celtics | |
| April | 12, 2022 | Rockets | | Bulls | |
| April | 13, 2022 | Knicks | | Bulls | |
| April | 14, 2022 | Bulls | | Heat | |
| April | 17, 2022 | Suns | | Bulls | |
| April | 19, 2022 | Bulls | | Cavaliers | |
| April | 20, 2022 | Grizzlies | | Bulls | |