| month | day | visitor | score | home | score |
|---|
| November | 3, 2021 | Grizzlies | 102 | 76ers | 118 |
| November | 4, 2021 | 76ers | 101 | Lakers | 105 |
| November | 5, 2021 | Bulls | 108 | 76ers | 111 |
| November | 7, 2021 | Suns | 84 | 76ers | 128 |
| November | 15, 2021 | Pistons | 110 | 76ers | 115 |
| November | 17, 2021 | 76ers | | Bulls | |
| November | 21, 2021 | 76ers | | Warriors | |
| November | 23, 2021 | Raptors | | 76ers | |
| November | 25, 2021 | Cavaliers | | 76ers | |
| November | 26, 2021 | Grizzlies | | 76ers | |
| November | 27, 2021 | Sonics | | 76ers | |
| November | 30, 2021 | 76ers | | Celtics | |
| December | 2, 2021 | 76ers | | Celtics | |
| December | 5, 2021 | Knicks | | 76ers | |
| December | 6, 2021 | 76ers | | Pistons | |
| December | 8, 2021 | Pistons | | 76ers | |
| December | 9, 2021 | 76ers | | Rockets | |
| December | 10, 2021 | 76ers | | Pistons | |
| December | 11, 2021 | Raptors | | 76ers | |
| December | 15, 2021 | 76ers | | Bulls | |
| December | 18, 2021 | 76ers | | Spurs | |
| December | 20, 2021 | 76ers | | Hornets | |
| December | 22, 2021 | Cavaliers | | 76ers | |
| December | 24, 2021 | Knicks | | 76ers | |
| December | 28, 2021 | 76ers | | Knicks | |
| December | 29, 2021 | Knicks | | 76ers | |
| December | 31, 2021 | 76ers | | Cavaliers | |
| January | 1, 2022 | 76ers | | Heat | |
| January | 4, 2022 | 76ers | | Knicks | |
| January | 8, 2022 | 76ers | | Cavaliers | |
| January | 12, 2022 | 76ers | | Raptors | |
| January | 14, 2022 | Lakers | | 76ers | |
| January | 15, 2022 | Bulls | | 76ers | |
| January | 18, 2022 | Jazz | | 76ers | |
| January | 19, 2022 | 76ers | | Knicks | |
| January | 22, 2022 | 76ers | | Celtics | |
| January | 24, 2022 | Spurs | | 76ers | |
| January | 27, 2022 | Warriors | | 76ers | |
| January | 28, 2022 | Celtics | | 76ers | |
| January | 29, 2022 | 76ers | | Heat | |
| February | 5, 2022 | 76ers | | Pistons | |
| February | 6, 2022 | Hornets | | 76ers | |
| February | 8, 2022 | 76ers | | Timberwolves | |
| February | 11, 2022 | Celtics | | 76ers | |
| February | 13, 2022 | 76ers | | Suns | |
| February | 14, 2022 | Pistons | | 76ers | |
| February | 15, 2022 | Bulls | | 76ers | |
| February | 17, 2022 | 76ers | | Nuggets | |
| February | 20, 2022 | 76ers | | Cavaliers | |
| February | 21, 2022 | 76ers | | Heat | |
| February | 26, 2022 | 76ers | | Raptors | |
| February | 27, 2022 | Cavaliers | | 76ers | |
| March | 2, 2022 | Bulls | | 76ers | |
| March | 4, 2022 | 76ers | | Raptors | |
| March | 6, 2022 | Heat | | 76ers | |
| March | 7, 2022 | Timberwolves | | 76ers | |
| March | 9, 2022 | 76ers | | Hornets | |
| March | 11, 2022 | Hornets | | 76ers | |
| March | 12, 2022 | 76ers | | Grizzlies | |
| March | 14, 2022 | 76ers | | Hornets | |
| March | 16, 2022 | 76ers | | Bulls | |
| March | 18, 2022 | Raptors | | 76ers | |
| March | 19, 2022 | 76ers | | Knicks | |
| March | 22, 2022 | Grizzlies | | 76ers | |
| March | 23, 2022 | 76ers | | Sonics | |
| March | 24, 2022 | 76ers | | Jazz | |
| March | 26, 2022 | Celtics | | 76ers | |
| March | 31, 2022 | Cavaliers | | 76ers | |
| April | 2, 2022 | Heat | | 76ers | |
| April | 3, 2022 | Hornets | | 76ers | |
| April | 4, 2022 | 76ers | | Grizzlies | |
| April | 6, 2022 | 76ers | | Heat | |
| April | 7, 2022 | 76ers | | Celtics | |
| April | 8, 2022 | Nuggets | | 76ers | |
| April | 9, 2022 | Rockets | | 76ers | |
| April | 10, 2022 | Clippers | | 76ers | |
| April | 13, 2022 | Hornets | | 76ers | |
| April | 14, 2022 | 76ers | | Grizzlies | |
| April | 15, 2022 | 76ers | | Clippers | |
| April | 17, 2022 | Heat | | 76ers | |
| April | 18, 2022 | Raptors | | 76ers | |
| April | 19, 2022 | 76ers | | Hornets | |